Baseline characteristics, response to and outcome of antiretroviral therapy among patients with HIV-1, HIV-2 and dual infection in Burkina Faso
Identifieur interne : 000958 ( Main/Exploration ); précédent : 000957; suivant : 000959Baseline characteristics, response to and outcome of antiretroviral therapy among patients with HIV-1, HIV-2 and dual infection in Burkina Faso
Auteurs : Katie Harries [Luxembourg (pays)] ; Rony Zachariah [Luxembourg (pays)] ; Marcel Manzi [Luxembourg (pays)] ; Peter Firmenich [Belgique] ; Richard Mathela [Burkina Faso] ; Joseph Drabo [Burkina Faso] ; G. Onadja [Burkina Faso] ; Line Arnould [Belgique] ; Anthony Harries [France, Royaume-Uni]Source :
- Transactions of The Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2010-02.
Descripteurs français
- Wicri :
- geographic : Burkina Faso.
English descriptors
Abstract
In an urban district hospital in Burkina Faso we investigated the relative proportions of HIV-1, HIV-2 and HIV-1/2 among those tested, the baseline sociodemographic and clinical characteristics, and the response to and outcome of antiretroviral therapy (ART). A total of 7368 individuals (male = 32%; median age = 34 years) were included in the analysis over a 6 year period (2002–2008). The proportions of HIV-1, HIV-2 and dual infection were 94%, 2.5% and 3.6%, respectively. HIV-1-infected individuals were younger, whereas HIV-2-infected individuals were more likely to be male, have higher CD4 counts and be asymptomatic on presentation. ART was started in 4255 adult patients who were followed up for a total of 8679 person-years, during which time 469 deaths occurred. Mortality differences by serotype were not statistically significant, but were generally worse for HIV-2 and HIV-1/2 after controlling for age, CD4 count and WHO stage. Among severely immune-deficient patients, mortality was higher for HIV-2 than HIV-1. CD4 count recovery was poorest for HIV-2. HIV-2 and dually infected patients appeared to do less well on ART than HIV-1 patients. Reasons may include differences in age at baseline, lower intrinsic immune recovery in HIV-2, use of ineffective ART regimens (inappropriate prescribing) by clinicians, and poor drug adherence.
Url:
DOI: 10.1016/j.trstmh.2009.08.012
Affiliations:
- Belgique, Burkina Faso, France, Luxembourg (pays), Royaume-Uni
- Angleterre, Grand Londres, Région de Bruxelles-Capitale, Île-de-France
- Bruxelles, Londres, Paris
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Le document en format XML
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Reasons may include differences in age at baseline, lower intrinsic immune recovery in HIV-2, use of ineffective ART regimens (inappropriate prescribing) by clinicians, and poor drug adherence.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>Burkina Faso</li><li>France</li><li>Luxembourg (pays)</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Région de Bruxelles-Capitale</li><li>Île-de-France</li></region><settlement><li>Bruxelles</li><li>Londres</li><li>Paris</li></settlement></list><tree><country name="Luxembourg (pays)"><noRegion><name sortKey="Harries, Katie" sort="Harries, Katie" uniqKey="Harries K" first="Katie" last="Harries">Katie Harries</name></noRegion><name sortKey="Manzi, Marcel" sort="Manzi, Marcel" uniqKey="Manzi M" first="Marcel" last="Manzi">Marcel Manzi</name><name sortKey="Zachariah, Rony" sort="Zachariah, Rony" uniqKey="Zachariah R" first="Rony" last="Zachariah">Rony Zachariah</name><name sortKey="Zachariah, Rony" sort="Zachariah, Rony" uniqKey="Zachariah R" first="Rony" last="Zachariah">Rony Zachariah</name></country><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Firmenich, Peter" sort="Firmenich, Peter" uniqKey="Firmenich P" first="Peter" last="Firmenich">Peter Firmenich</name></region><name sortKey="Arnould, Line" sort="Arnould, Line" uniqKey="Arnould L" first="Line" last="Arnould">Line Arnould</name></country><country name="Burkina Faso"><noRegion><name sortKey="Mathela, Richard" sort="Mathela, Richard" uniqKey="Mathela R" first="Richard" last="Mathela">Richard Mathela</name></noRegion><name sortKey="Drabo, Joseph" sort="Drabo, Joseph" uniqKey="Drabo J" first="Joseph" last="Drabo">Joseph Drabo</name><name sortKey="Onadja, G" sort="Onadja, G" uniqKey="Onadja G" first="G." last="Onadja">G. 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